Efficient noninferiority testing procedures for simultaneously assessing sensitivity and specificity of two diagnostic tests (Q304704)
From MaRDI portal
scientific article
Language | Label | Description | Also known as |
---|---|---|---|
English | Efficient noninferiority testing procedures for simultaneously assessing sensitivity and specificity of two diagnostic tests |
scientific article |
Statements
Efficient noninferiority testing procedures for simultaneously assessing sensitivity and specificity of two diagnostic tests (English)
0 references
26 August 2016
0 references
Summary: Sensitivity and specificity are often used to assess the performance of a diagnostic test with binary outcomes. Wald-type test statistics have been proposed for testing sensitivity and specificity individually. In the presence of a gold standard, simultaneous comparison between two diagnostic tests for noninferiority of sensitivity and specificity based on an asymptotic approach has been studied by \textit{J. J. Chen}, \textit{H.-M. Hsueh} and \textit{J.-P. Liu} [``Simultaneous non-inferiority test of sensitivity and specificity for two diagnostic procedures in the presence of a gold standard'', Biom. J. 45, No. 1, 47--60 (2003; \url{doi:10.1002/bimj.200290015})]. However, the asymptotic approach may suffer from unsatisfactory type I error control as observed from many studies, especially in small to medium sample settings. In this paper, we compare three unconditional approaches for simultaneously testing sensitivity and specificity. They are approaches based on estimation, maximization, and a combination of estimation and maximization. Although the estimation approach does not guarantee type I error, it has satisfactory performance with regard to type I error control. The other two unconditional approaches are exact. The approach based on estimation and maximization is generally more powerful than the approach based on maximization.
0 references
Wald-type test statistics
0 references
diagnostic tests
0 references
type I error
0 references
sensitivity and specificity
0 references
0 references
0 references
0 references
0 references