Prediction of high-risk types of human papillomaviruses using statistical model of protein ``sequence space'' (Q308843)

Summary: Discrimination of high-risk types of human papillomaviruses plays an important role in the diagnosis and remedy of cervical cancer. Recently, several computational methods have been proposed based on protein sequence-based and structure-based information, but the information of their related proteins has not been used until now. In this paper, we proposed using protein ``sequence space'' to explore this information and used it to predict high-risk types of HPVs. The proposed method was tested on 68 samples with known HPV types and 4 samples without HPV types and further compared with the available approaches. The results show that the proposed method achieved the best performance among all the evaluated methods with accuracy 95.59\% and F1-score 90.91\%, which indicates that protein ``sequence space'' could potentially be used to improve prediction of high-risk types of HPVs.