wTO (Q32116)
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Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | wTO |
Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network |
Statements
4 July 2024
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Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at <doi:10.1186/s12859-018-2351-7>.
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Andre Voigt
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Tiago Miranda Fragoso
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Eivind Almaas
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Katja Nowick.
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