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The book deals with the difficult and complex problems arising in elaborating territorial programs for regional development. The main difficulties are connected with the comprehensive interbranch nature of the regional problems combining the activity of several branches of the economy, the project of regional development including such aspects as infrastructure development, transportation networks, optimal utilization of natural, material and labour resources and environmental problems. The difficulties in solving such complex problems come also from their multicriterial objectives and highly combinatorial nature. The book has 8 chapters: Chapter 1 introduces the regional programming problem as a dynamic system problem. The approximation combinatorial method of composition and decomposition of systems and its application to the solution of regional programming problems is substantiated in chapter 2, while in chapter 3 approximate combinatorial solution methods for some discrete optimization problems as well as modifications of linear and dynamic programming methods and the sequential computational methods are presented. Problems concerning the optimal allocation of enterprises, of territorial production complexes and of optimal networks structures as well as the optimization of networks with a given structure are presented in chapters 4 to 7. Chapter 8 presents some problems of regional programming solved by synthesis of branch development schemes and allocation of productive forces and in chapter 9 three computer-aided system projections, namely for the development of oil-fields and oil-gas-fields, and for planning and projecting of agro-production regions, are described. The monograph generalizes the scientific results obtained by the author and his collaborators for a long period and it is claimed that the methods and algorithms under consideration have been tested and have proved their efficiency. The 164 references cover only the Russian literature on the subject.