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This comprehensive and up-to-date monograph covers the fundamentals and recent developments in the mathematical modeling of metabolic systems, providing the basis for improved understanding of the behavior and functioning of cells. In particular, it presents state-of-the-art theoretical descriptions of the regulation of enzymatic systems, including coverage of stoichiometric, kinetik and control and optimality properties. The volume begins with coverage of enzymatic rate laws and stoichiometric analysis. It then presents a detailed account of the interpretation of time hierarchy. A considerable amount of the text is devoted to the next section on metabolic control analysis. The book provides a thorough overview on this topic, from its basic definitions to its more detailed and computational aspects. Finally, various approaches describing optimality properties of enzymatic systems and their interrelations with biological evolution are outlined. Other highlights of this text include metabolic channeling, metabolic oscillations, and modular treatment, as well as a multitude of illustrations and an abundant reference list. It is an exceptional textbook for faculty and graduate students in departments of cellular and molecular biology, neurobiology, biophysics and biomedical research departments.