Natural parameter conditions for singular perturbations of chemical and biochemical reaction networks (Q6044243)

In this paper, the authors consider reaction networks that admit a singular perturbation reduction in a certain parameter range. They focus on deriving ``small parameters'' to gauge the accuracy of the reduction based on local timescale estimates via ratios of the real parts of eigenvalues of the Jacobian near critical manifolds, and obtain distinguished parameters for systems of arbitrary dimension. As applications, they discuss the Michaelis-Menten reaction mechanism system in various settings and more complex enzyme catalyzed reaction mechanisms of dimension three.