Multi-layered tumor cell cultures with almost periodic nutrient supply (Q6060930)

Summary: Modeling of multi-layered cell cultures (MCC) assume flat geometry in a 3D tumor growth model. Some results available in the time-dependent framework assume a periodic nutrient supply \(\Phi (t)\). Our aim is to generalize such considerations. Namely, we show that a stable oscillating tumor growth arises in the long term, whenever the mean value of the almost periodic nutrient supply \(\overline{\Phi}\) surpasses certain threshold level, \(\overline{\Phi} > \tilde{\sigma}\). Meanwhile, a vanishing tumor is predicted in the complementary case, \(\overline{\Phi}\leq \tilde{\sigma}\).