Neuronal activity induces symmetry breaking in neurodegenerative disease spreading (Q6553210)

Slow-fast dynamics on a network are used to simulate the progression of Alzheimer's disease. The system proposed by the authors treats the different timescales arising from the protein spreading and neuronal activity, two processes which admit a feedback mechanism. The authors present their study on the dynamics of heterodimer spreading in a system of Kuramoto oscillators, and show certain neuronal oscillatory activity corresponds to toxic protein outbreaks that in turn is responsible for symmetry breaking in the spread patterns. Numerical simulations are also given.