Mathematical generation of data-driven hippocampal CA1 pyramidal neurons and interneurons copies via A-GLIF models for large-scale networks covering the experimental variability range (Q6566653)

In this work, the authors introduce a novel methodology to implement copies representing the different firing dynamics of CA1 neurons and interneurons, by perturbing specific parameters in the adaptive generalized leaky integrate-and-fire (A-GLIF) model. It is shown how it is possible to control the dynamical behavior of the copies and, at the same time, to remain bounded within the experimental range. A full set of heterogeneous neurons composing the CA1 region of a rat hippocampus (approximately 1.2 million neurons), are provided in a database freely available in the live paper section of the EBRAINS platform. The code can be easily extended to generate an arbitrary larger population, to consider other brain regions. The numerical strategy adopted for the classification of any given neuron copy as member of the pyramidal/interneurons classes is illustrated. Different cloning procedures and the algorithm to generate copies with controlled firing properties are discussed in Section 3.