chestR (Q7370980)
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Kernel-Weighted Cox Regression for Treatment Effect Heterogeneity
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
||
| English | chestR |
Kernel-Weighted Cox Regression for Treatment Effect Heterogeneity |
Statements
Explores treatment effect heterogeneity and candidate predictive biomarkers by re-fitting weighted Cox proportional hazards models on a biomarker grid. Kernel weights centred at each grid point produce local coefficient estimates that can be visualised across biomarker space. Builds on ideas related to graphical Cox treatment-covariate interaction methods [see Bonetti and Gelber (2004) <doi:10.1093/biostatistics/kxh002> and local partial-likelihood approaches Fan, Lin and Zhou (2006) <doi:10.1214/009053605000000796>].
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12 September 2026
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Caroline Jeffery
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