mSigSpectra (Q7388632)
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Build Mutational-Spectrum Catalogs from Variant Call Format Files
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | mSigSpectra |
Build Mutational-Spectrum Catalogs from Variant Call Format Files |
Statements
Reads variant call format (VCF) files in a caller-agnostic way, annotates variants with flanking sequence context and transcriptional strand, and builds mutational-spectrum catalogs of single base substitutions (SBS), doublet base substitutions (DBS), and small insertions and deletions (indels, ID) at several resolutions (SBS96, SBS192, SBS1536, DBS78, DBS136, DBS144, ID83, ID89, ID166, ID476) and in both counts and density representations. Successor to the numerical core of the 'ICAMS' package with plotting, 'shiny', and portable document format (PDF) reporting removed; plotting is provided separately by 'mSigPlot'. Used in the preparation of Rozen et al. (2026) <doi:10.5281/zenodo.18451842>.
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27 September 2026
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Nanhai Jiang
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Arnoud Boot
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Mo Liu
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Yang Wu
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Mi Ni Huang
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Jia Geng Chang
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