simIDM (Q79278)
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Simulating Oncology Trials using an Illness-Death Model
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | simIDM |
Simulating Oncology Trials using an Illness-Death Model |
Statements
11 December 2023
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Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.
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