simIDM

Simulating Oncology Trials using an Illness-Death Model

Daniel Sabanés Bové, Kaspar Rufibach, Alexandra Erdmann, Holger Löwe

Last update: 11 December 2023

Copyright license: Apache License, Version 2.0

Software version identifier: 0.0.5, 0.1.0

Description

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

Cites work

Joint modeling of progression‐free and overall survival and computation of correlation measures

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