Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle (Q794952)

The author first gives a detailed review of two distinct models which were originally presented by \textit{J. F. Crow} and \textit{M. Kimura} [The theory of genetic loads. Proc. XI Int. Congr. Genet., 495-505, (1964)] and \textit{B. Latter} [Natural selection for an intermediate optimum. Aust. J. Biol. Sci. 13, 30-35 (1960)], respectively, and which were used by several authors to explain the genetic variation of quantitative traits being controlled by additive polygenic loci subject to mutation and stability selection. It is pointed out that in the studies based on the ''Crow-Kimura-model'' certain mathematical assumptions are in general not justified. The author then presents a new approximation of the ''Crow-Kimura-model'' the results of which are in agreement with those obtained on the basis of the ''Latter-model''. Numerical results are given to show in what cases the different approximations are valid. A critical review of the empirical data available and the procedures for estimation of mutation rates and selection intensities completes the study which is an important contribution to unify the different analyses of mutation-selection balance for additive polygenic traits.