An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling (Q798270)
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scientific article; zbMATH DE number 3869108
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| English | An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling |
scientific article; zbMATH DE number 3869108 |
Statements
An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling (English)
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1984
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Time required for transfer of material from one compartment to another is often not neglegible. The method presented in this paper allows to get the analytic solution of a delayed differential system connected with an n-compartment model with constant time with a single input, and by convolution for all intakes. This is applied to the case of one-, two-, and three-compartments. The amount of drug in any compartment is expressed for all time, and the mean residence times are obtainable.
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delay-differential equations
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time lags
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pharmacokinetics of drug
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enterohepatic circulation
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analytic solution
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n-compartment model
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mean residence times
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0.8019137382507324
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