Resonance phenomena in cell population chemotherapy models (Q809008)

A resonance effect in periodic chemotherapy, discovered by \textit{B. F. Dibrov, A. M. Zhabotinsky, Yu. A. Neyfakh, M. P. Orlova} and \textit{L. I. Churikova} [Math. Biosci. 73, 1-31 (1985; Zbl 0565.92006)], can be described as follows. If the period of the chemotherapy is close to the mean cycle length of normal cells and if the mean cycle length of the tumor cells is significantly longer than that of normal cells then fewer normal cells are destroyed than tumor cells. Dibrov et al studied age- structured models of cell populations. In this paper, it is shown that the resonance effect occurs also in more refined cell population models, i.e., age-size structured models. Four examples of classes of age-size structured models are described and analyzed.