betaclust (Q86081)
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A Family of Beta Mixture Models for Clustering Beta-Valued DNA Methylation Data
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | betaclust |
A Family of Beta Mixture Models for Clustering Beta-Valued DNA Methylation Data |
Statements
29 September 2023
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A family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) <arXiv:2211.01938v1> to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.
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