betaclust
A Family of Beta Mixture Models for Clustering Beta-Valued DNA Methylation Data
Andrea Rau, Koyel Majumdar, Florence Jaffrezic, Antoinette Sabrina Perry, Thomas Brendan Murphy, Ronald William Watson, Romina Silva, Isobel Claire Gormley
Last update: 29 September 2023
Copyright license: GNU General Public License, version 3.0
Software version identifier: 1.0.0, 1.0.3
A family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) <arXiv:2211.01938v1> to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.
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