Local alignment of Markov chains (Q862205)
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| English | Local alignment of Markov chains |
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Local alignment of Markov chains (English)
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5 February 2007
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This paper investigates local alignments without gaps of two independent Markov chains from a finite alphabet. Sufficient conditions are established for the number of essentially different local alignments with a score exceeding a high threshold to be asymptotically Poisson distributed. From the Poisson approximation a Gumbel approximation of the maximal local alignment score is obtained. The results extend known results for independent sequences of i.i.d random variables.
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Chen-Stein method
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extreme value theory
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large deviations
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local alignment
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Markov additive processes
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Poisson approximation
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0.8696394
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0.8623596
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0.86031973
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0.86007464
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0.85546494
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0.8462072
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0.8461263
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