Hopf bifurcation in a delayed model for tumor-immune system competition with negative immune response (Q871380)

Summary: The dynamics of a model for tumor-immune system competition with negative immune response and with one delay is investigated. We show that the asymptotic behavior depends crucially on the time delay parameter. We are particularly interested in the study of the Hopf bifurcation problem to predict the occurrence of a limit cycle bifurcating from the nontrivial steady state, by using the delay as a parameter of bifurcation. The obtained results provide the oscillations given by the numerical study of \textit{M. Gałach} [Int. J. Appl. Math. Comput. Sci. 13, No. 3, 395--406 (2003; Zbl 1035.92019)], which are observed in reality by \textit{D. Kirschner} and \textit{J. C. Panetta} [J. Math. Biol. 37, No. 3, 235--252 (1998; Zbl 0902.92012)].