Modelling the hepatitis C with different types of virus genome (Q883736)

Summary: Hepatitis C virus (HCV) is one of the leading known causes of liver disease in the world. The HCV is a single-stranded RNA virus. The genomes of HCV display significant sequence heterogeneity and have been classified into types and subtypes. Types from 1 to 11 have so far been recognized, each type having a variable number of subtypes. It has been confirmed that 90\% approximately of the isolates HCV infections in Egypt belong to a single subtype (4a). We construct a mathematical model to study the spread of HCV-subtype 4a amongst the Egyptian population. The relation between HCV-subtype 4a and the other subtypes has also been studied. The values of reproduction numbers \(R_{01}\), \(R_{02}\) have been derived. Also, threshold conditions for the value of the transmission rates \(k_1\) and \(k_{02}\), in terms of \(R_{01}\), \(R_{02}\) and the mutation factor have been determined to insure that the disease will die out. If the conditions fail to happen the disease takes off and becomes endemic.