Reversible-equivalent-monomolecular tau: a leaping method for ``small number and stiff'' stochastic chemical systems (Q886074)

The authors propose a new numerical scheme called REMM-\(\tau\) (reversible-equivalent-monomolecular-tau) in order to simulate biological stiff systems, involving dynamics with very different time scales. This scheme is based on the fact that the exact solution for two prototypical monomolecular reversible reactions as a function of time takes a simple form. The method is illustrated by a comparison with implicit algorithms.