Allele frequencies in multigene families. I: Diffusion equation approach (Q909596)
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scientific article; zbMATH DE number 4137573
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| English | Allele frequencies in multigene families. I: Diffusion equation approach |
scientific article; zbMATH DE number 4137573 |
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Allele frequencies in multigene families. I: Diffusion equation approach (English)
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1989
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This paper explores several properties of a model of \textit{A. Shimizu} [see Stochastic methods in biology, Proc. Workshop, Nagoya/Jap. 1985, Lect. Notes Biomath. 70, 100-114 (1987; Zbl 0644.92010)] for the evolution of a population of chromosomes using a diffusion approach. The model includes mutation and gene conversion within a multigene family on the chromosomes. In particular, the author shows why Ewens sampling formula emerges in this context. The theory is also extended to obtain transient and stationary results for the sampling distribution. Expectations, variances and covariances for the numbers of alleles across the chromosomes are calculated. Some numerical examples are included.
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diffusion equation approach
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mutation
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gene conversion
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multigene family
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Ewens sampling formula
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transient and stationary results
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sampling distribution
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Expectations
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variances
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covariances
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numbers of alleles
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numerical examples
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0.8414402008056641
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0.8207889795303345
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0.8125004172325134
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0.7987813353538513
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