Modelling immune response and drug therapy in human malaria infection (Q937809)
From MaRDI portal
scientific article
Language | Label | Description | Also known as |
---|---|---|---|
English | Modelling immune response and drug therapy in human malaria infection |
scientific article |
Statements
Modelling immune response and drug therapy in human malaria infection (English)
0 references
15 August 2008
0 references
Summary: A new intra-host model of malaria that describes the dynamics of the blood stages of the parasite and its interaction with red blood cells and immune effectors is proposed. Local and global stability of the disease free equilibrium are investigated. Conditions for existence and uniqueness of the endemic equilibrium are derived. An intra-host basic reproductive number is identified. We deduce that drugs based on inhibiting parasite production are more effective than those based on inhibiting merozoite invasion of erythrocytes. We extend the model to incorporate, in addition to immune response, drug therapy, following treatment with antimalarial drugs. Using stability analysis of the model, it is shown that the infection can be eradicated within the host if the drug efficacy level exceeds a certain threshold value. It will persist if the efficacy is below this threshold. Numerical simulations are done to verify the analytic results and illustrate the possible behaviour of the models.
0 references
intra-host
0 references
reproductive numbe
0 references
efficacy
0 references