Local Stereology

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This is the first systematic and unified exposition of the mathematical and statistical background of local stereology. Local stereological methods were developed over the last fifteen years driven by advances in the microscopy observation techniques and theoretical results in integral geometry and geometric probability. The target of local stereology is quantitative parameters of structures which can be regarded as neighbourhoods of (reference) points, e.g. cells being regarded as neighbourhoods of their nuclei. Local stereology develops sampling designs based on sections through the reference points in order to estimate parameters of the underlying structure. The book starts with an elementary introduction to mathematical stereology. Further chapters are devoted to local stereology with emphasis on the relevant mathematical tools: the coarea formula, measures on linear subspaces, geometric decomposition of Lebesgue and Hausdorff measures (known as Blaschke-Petkantschin formulae), local slice and projection formulae. The final chapters discuss practical implementations of local stereological techniques and the model-based approach where the underlying geometric structure is determined by marked point processes (while the most part of the book deals with design-based approach presuming the structure is fixed and a sample is random). The potential readers of this book will belong to several groups: probabilists (with interest in stochastic geometry), statisticians (who may be inspired by the nature of geometric sampling problems), pure mathematicians (who are interested in applications of integral geometry and geometric measure theory) and mathematically literate microscopists (who will appreciate the clear presentation of the background of a number of stereological techniques). The book is self-contained, and well-readable with a number of explanatory figures. All chapters are followed by useful exercises and bibliographical notes. Overall, this book is going to become a standard graduate text on design-based local stereology.




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