Low-Dose-Rate Extrapolation Using the Multistage Model

DOI10.2307/2531325MaRDI QIDQ3321304zbMATH OpenOpenAlexWikidataFDO

Authors Christopher J. Portier, David G. Hoel

Publication date 1983

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.2307/2531325

zbMATH Keywords

Armitage-Doll multistage modelbimodal distributions for small bioassaysdistribution of the maximum likelihood estimates of virtually safe levels of exposure to environmental chemicalslarge-sample theorylow-dose-rate extrapolationMonte Carlo simulation

Mathematics Subject Classification ID

Asymptotic distribution theory in statistics (62E20) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited in

(14)

• Estimation of extra risk and benchmark dose in dose-response models
• A Lagrange-Gamma multihit dose-response model for risk assessment
• A model for estimating environmental risk using multidimensional quantal response surfaces
• Locally D-optimal designs for multistage models and heteroscedastic polynomial regression models
• An algorithm for the MSAE estimation of the multistage dose-response model
• An Increasing Failure Rate Approach to Low-Dose Extrapolation
• Bootstrap bounds for “safe” doses in the multistage cancer dose-response model
• scientific article; zbMATH DE number 3907630 (Why is no real title available?)
• An iterative procedure for the estimation of parameters in a dose-response model
• Optimal Designs for Estimating the Percentiles of the Risk in Multistage Models of Carcinogenesis
• Environmental risk assessment model for low dose extrapolation^∗
• On tests of linearity for dose response data: Asymptotic, exact conditional and exact unconditional tests
• Some aspects of maximum likelihood estimation of multistage cancer dose-response odels with application
• An increasing hazard rate approach to multivariate low-dose extrapolation

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