Matching on-the-fly: sequential allocation with higher power and efficiency

DOI10.1111/BIOM.12148MaRDI QIDQ5170207zbMATH OpenOpenAlexWikidataFDO

Authors Adam Kapelner, Abba M. Krieger

Publication date 22 July 2014

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1305.4981, https://repository.upenn.edu/cgi/viewcontent.cgi?article=1660&context=statistics_papers

zbMATH Keywords

alternatives to randomizationclinical trialsmatchingsequential allocationsquared Mahalanobis distance

Mathematics Subject Classification ID

Sequential statistical design (62L05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials. Subjects arrive iteratively and are either randomized or paired via a matching criterion to a previously randomized subject and administered the alternate treatment. We develop estimators for the average treatment effect that combine information from both the matched pairs and unmatched subjects as well as an exact test. Simulations illustrate the method's higher efficiency and power over competing allocation procedures in both controlled scenarios and historical experimental data.

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Cites work

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Cited in

(11)

• Power efficiency of Efron's biased coin design
• Adaptive Allocation Design for Matching Pairs
• OptimalA PrioriBalance in the Design of Controlled Experiments
• Covariate-adaptive optimization in online clinical trials
• A matching procedure for sequential experiments that iteratively learns which covariates improve power
• Better experimental design by hybridizing binary matching with imbalance optimization
• Pair-Switching Rerandomization
• Subgroup analysis and adaptive experiments crave for debiasing
• Rematching on-the-fly: sequential matched randomization and a case for covariate-adjusted randomization
• k-resolution sequential randomization procedure to improve covariates balance in a randomized experiment
• Randomization, matching, and propensity scores in the design and analysis of experimental studies with measured baseline covariates

Describes a project that uses

Uses Software

• BayesTree
• DOS
• BartPy

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