Maximum likelihood estimation under the Emax model: existence, geometry and efficiency

DOI10.1007/S00362-025-01673-2MaRDI QIDQ6947672zbMATH OpenFDO

Authors Giacomo Aletti, Nancy Flournoy, Caterina May, Chiara Tommasi

Publication date 5 August 2025

Published in Statistical Papers (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/S00362-025-01673-2

zbMATH Keywords

D-optimum experimental designdose-findingnonlinear regressionscore modification

Mathematics Subject Classification ID

Point estimation (62F10) Generalized linear models (logistic models) (62J12) Optimal statistical designs (62K05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Bias reduction in exponential family nonlinear models
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• Longitudinal model for a dose-finding study for a rare disease treatment
• Mean and median bias reduction in generalized linear models
• Multinomial logit bias reduction via the Poisson log-linear model
• On the efficiency of two-stage response-adaptive designs
• Optimal design for nonlinear response models
• Optimal designs for the emax, log-linear and exponential models
• Optimum experimental designs, with SAS
• Performance Measures in Dose‐Finding Experiments
• The effects of adaptation on maximum likelihood inference for nonlinear models with normal errors

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