Maximum principle and mutation thresholds for four-letter sequence evolution

DOI10.1088/1742-5468/2004/07/P07007MaRDI QIDQ3160059zbMATH OpenOpenAlexFDO

Authors Tini Garske, Uwe Grimm

Publication date 1 February 2005

Published in Journal of Statistical Mechanics: Theory and Experiment (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0406041

zbMATH Keywords

new applications of statistical mechanicspopulation dynamics (theory)quantum phase transitions (theory)

Mathematics Subject Classification ID

Dynamic and nonequilibrium phase transitions (general) in statistical mechanics (82C26) Applications of statistical mechanics to specific types of physical systems (82D99) Genetics and epigenetics (92D10)

Abstract: A four-state mutation-selection model for the evolution of populations of DNA-sequences is investigated with particular interest in the phenomenon of error thresholds. The mutation model considered is the Kimura 3ST mutation scheme, fitness functions, which determine the selection process, come from the permutation-invariant class. Error thresholds can be found for various fitness functions, the phase diagrams are more interesting than for equivalent two-state models. Results for (small) finite sequence lengths are compared with those for infinite sequence length, obtained via a maximum principle that is equivalent to the principle of minimal free energy in physics.

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