Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states

DOI10.1007/S10955-009-9732-2MaRDI QIDQ2390955zbMATH OpenOpenAlexFDO

Authors Enrique Muñoz, Jeong-Man Park, Michael W. Deem

Publication date 10 August 2009

Published in Journal of Statistical Physics (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial 4.0 International

Full work available at URL https://arxiv.org/abs/0903.2004

zbMATH Keywords

error catastropheevolution alphabet sizemolecular evolutionsquasi-species theory

Mathematics Subject Classification ID

Problems related to evolution (92D15) Model quantum field theories (81T10) Dynamic and nonequilibrium phase transitions (general) in statistical mechanics (82C26) Statistical mechanics of polymers (82D60) Classical dynamic and nonequilibrium statistical mechanics (general) (82C05)

Abstract: To represent the evolution of nucleic acid and protein sequence, we express the parallel and Eigen models for molecular evolution in terms of a functional integral representation with an $h$-letter alphabet, lifting the two-state, purine/pyrimidine assumption often made in quasi-species theory. For arbitrary $h$ and a general mutation scheme, we obtain the solution of this model in terms of a maximum principle. Euler's theorem for homogeneous functions is used to derive this `thermodynamic' formulation of evolution. The general result for the parallel model reduces to known results for the purine/pyrimidine $h=2$ alphabet and the nucleic acid $h=4$ alphabet for the Kimura 3 ST mutation scheme. Examples are presented for the $h=4$ and $h=20$ cases. We derive the maximum principle for the Eigen model for general $h$. The general result for the Eigen model reduces to a known result for $h=2$. Examples are presented for the nucleic acid $h=4$ and the amino acid $h=20$ alphabet. An error catastrophe phase transition occurs in these models, and the order of the phase transition changes from second to first order for smooth fitness functions when the alphabet size is increased beyond two letters to the generic case. As examples, we analyze the general analytic solution for sharp peak, linear, quadratic, and quartic fitness functions.

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Cites work

• scientific article; zbMATH DE number 3273551 (Why is no real title available?)
• scientific article; zbMATH DE number 3390587 (Why is no real title available?)
• An asymptotic maximum principle for essentially linear evolution models
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• Four-state quantum chain as a model of sequence evolution.
• Maximum principle and mutation thresholds for four-letter sequence evolution
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• Partial differential equations. 4th ed
• Schwinger boson formulation and solution of the crow-kimura and eigen models of quasispecies theory

Cited in

(7)

• Spin coherent state representation of the Crow-Kimura and Eigen models of quasispecies theory
• Diffusion on a hypercubic lattice with pinning potential: exact results for the error-catastrophe problem in biological evolution
• Schwinger boson formulation and solution of the crow-kimura and eigen models of quasispecies theory
• Critical population and error threshold on the sharp peak landscape for a Moran model
• Long range anti-ferromagnetic spin model for prebiotic evolution
• Maximum principle and mutation thresholds for four-letter sequence evolution
• Non-Archimedean replicator dynamics and Eigen's paradox

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