Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states

DOI10.1007/S10955-009-9732-2zbMATH Open1175.82035arXiv0903.2004OpenAlexW3106490163MaRDI QIDQ2390955FDOQ2390955

Michael W. Deem, Jeong-Man Park, Enrique Muñoz

Publication date: 10 August 2009

Published in: Journal of Statistical Physics (Search for Journal in Brave)

Abstract: To represent the evolution of nucleic acid and protein sequence, we express the parallel and Eigen models for molecular evolution in terms of a functional integral representation with an $h$-letter alphabet, lifting the two-state, purine/pyrimidine assumption often made in quasi-species theory. For arbitrary $h$ and a general mutation scheme, we obtain the solution of this model in terms of a maximum principle. Euler's theorem for homogeneous functions is used to derive this `thermodynamic' formulation of evolution. The general result for the parallel model reduces to known results for the purine/pyrimidine $h=2$ alphabet and the nucleic acid $h=4$ alphabet for the Kimura 3 ST mutation scheme. Examples are presented for the $h=4$ and $h=20$ cases. We derive the maximum principle for the Eigen model for general $h$. The general result for the Eigen model reduces to a known result for $h=2$. Examples are presented for the nucleic acid $h=4$ and the amino acid $h=20$ alphabet. An error catastrophe phase transition occurs in these models, and the order of the phase transition changes from second to first order for smooth fitness functions when the alphabet size is increased beyond two letters to the generic case. As examples, we analyze the general analytic solution for sharp peak, linear, quadratic, and quartic fitness functions.

Full work available at URL: https://arxiv.org/abs/0903.2004

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zbMATH Keywords

error catastropheevolution alphabet sizemolecular evolutionsquasi-species theory

Mathematics Subject Classification ID

Problems related to evolution (92D15) Model quantum field theories (81T10) Dynamic and nonequilibrium phase transitions (general) in statistical mechanics (82C26) Statistical mechanics of polymers (82D60) Classical dynamic and nonequilibrium statistical mechanics (general) (82C05)

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