Modeling the complex dynamics and changing correlations of epileptic events
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Abstract: Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied quantitatively---could yield important insights into the nature and intrinsic dynamics of seizures. A goal of our work is to parse these complex epileptic events into distinct dynamic regimes. A challenge posed by the intracranial EEG (iEEG) data we study is the fact that the number and placement of electrodes can vary between patients. We develop a Bayesian nonparametric Markov switching process that allows for (i) shared dynamic regimes between a variable number of channels, (ii) asynchronous regime-switching, and (iii) an unknown dictionary of dynamic regimes. We encode a sparse and changing set of dependencies between the channels using a Markov-switching Gaussian graphical model for the innovations process driving the channel dynamics and demonstrate the importance of this model in parsing and out-of-sample predictions of iEEG data. We show that our model produces intuitive state assignments that can help automate clinical analysis of seizures and enable the comparison of sub-clinical bursts and full clinical seizures.
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Cites work
- scientific article; zbMATH DE number 1085980 (Why is no real title available?)
- scientific article; zbMATH DE number 1911984 (Why is no real title available?)
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Cited in
(9)- Onset of polyspike complexes in a mean-field model of human electroencephalography and its application to absence epilepsy
- Cooperative hierarchical Dirichlet processes: superposition vs. maximization
- Evolving Network Model That Almost Regenerates Epileptic Data
- Synaptic plasticity based model for epileptic seizures
- Computational Sensitivity Analysis on a Mathematical Model of Epileptic Seizures
- A Bayesian nonparametric model for multi-label learning
- Nonparametric multi-level clustering of human epilepsy seizures
- The Convex Mixture Distribution: Granger Causality for Categorical Time Series
- Epilepsziás agyi hálózatok egysejt-aktivitásának jellemzése Hawkes-folyamatok segítségével
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