Evolving Network Model That Almost Regenerates Epileptic Data

DOI10.1162/NECO_A_00941MaRDI QIDQ5380679zbMATH OpenOpenAlexWikidataFDO

Authors G. Manjunath

Publication date 6 June 2019

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1611.09245

zbMATH Keywords

epileptic seizuresevolving neural network modeltime-varying interconnections

Mathematics Subject Classification ID

Medical applications (general) (92C50) Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: In many realistic networks, the edges representing the interactions between the nodes are time-varying. There is growing evidence that the complex network that models the dynamics of the human brain has time-varying interconnections, i.e., the network is evolving. Based on this evidence, we construct a patient and data specific evolving network model (comprising discrete-time dynamical systems) in which epileptic seizures or their terminations in the brain are also determined by the nature of the time-varying interconnections between the nodes. A novel and unique feature of our methodology is that the evolving network model remembers the data from which it was conceived from, in the sense that it evolves to almost regenerate the patient data even upon presenting an arbitrary initial condition to it. We illustrate a potential utility of our methodology by constructing an evolving network from clinical data that aids in identifying an approximate seizure focus -- nodes in such a theoretically determined seizure focus are outgoing hubs that apparently act as spreaders of seizures. We also point out the efficacy of removal of such spreaders in limiting seizures.

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Cited in

(5)

• Evolving graphs: dynamical models, inverse problems and propagation
• Identifying influential nodes in a network model of epilepsy
• Modeling the complex dynamics and changing correlations of epileptic events
• Stability and memory-loss go hand-in-hand: three results in dynamics and computation
• Epilepsziás agyi hálózatok egysejt-aktivitásának jellemzése Hawkes-folyamatok segítségével

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