Modelling population-level Hes1 dynamics: insights from a multi-framework approach

DOI10.1007/S11538-025-01447-9MaRDI QIDQ6952331zbMATH OpenFDO

Authors Gesina Menz, Stefan Engblom

Publication date 28 July 2025

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/S11538-025-01447-9

zbMATH Keywords

cellular synchronisationfate decisiongenetic oscillatorneurogenesispattern formation

Mathematics Subject Classification ID

Ordinary lattice differential equations (34A33) Qualitative investigation and simulation of ordinary differential equation models (34C60) Bifurcation of solutions to ordinary differential equations involving randomness (34F10) Developmental biology, pattern formation (92C15) Neural biology (92C20)

Cites work

• An introduction to systems biology. Design principles of biological circuits.
• Dissecting the dynamics of the Hes1 genetic oscillator
• Effect of time delay on pattern formation: Competition between homogenisation and patterning
• scientific article; zbMATH DE number 3951715 (Why is no real title available?)
• scientific article; zbMATH DE number 3968590 (Why is no real title available?)
• Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis
• Multistability and transitions between spatiotemporal patterns through versatile Notch-Hes signaling
• Simulation of stochastic reaction-diffusion processes on unstructured meshes
• Stochastic simulation of pattern formation in growing tissue: a multilevel approach
• The role of dimerisation and nuclear transport in the Hes1 gene regulatory network

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