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MaRDI QIDQ91856CRANFDO

Authors John Kirkpatrick

Last update 22 December 2025

Copyright license GNU General Public License

Software version identifier 0.1.0, PACKAGES.rds, 0.1.2, 0.1.3, 0.1.4

Description

Implements Mander & Thompson's (2010) <doi:10.1016/j.cct.2010.07.008> methods for two-stage designs optimal under the alternative hypothesis for phase II [cancer] trials. Also provides an implementation of Simon's (1989) <doi:10.1016/0197-2456(89)90015-9> original methodology and allows exploration of the operating characteristics of sub-optimal designs.

Cites work

• Optimal two-stage designs for phase II clinical trials
• Two-stage designs optimal under the alternative hypothesis for phase II cancer clinical trials

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