Multi-arm group sequential designs with a simultaneous stopping rule

DOI10.1002/SIM.7077MaRDI QIDQ6918920zbMATH OpenFDO

Authors S. Urach, Markus Posch

Publication date 9 October 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial 3.0 Unported

Full work available at URL https://doi.org/10.1002/SIM.7077

zbMATH Keywords

closed testingearly stoppingmulti-arm multi-stage designsmultiple comparisonsmultiple treatment arms

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection
• A group sequential Holm procedure with multiple primary endpoints
• Allocating recycled significance levels in group sequential procedures for multiple endpoints
• Flexible sequential designs for multi-arm clinical trials
• Group Sequential Tests for Delayed Responses (with discussion)
• Monitoring Pairwise Comparisons in Multi-Armed Clinical Trials
• On group sequential tests for data in unequally sized groups and with unknown variance
• P Values Maximized Over a Confidence Set for the Nuisance Parameter
• Statistical monitoring of clinical trials. A unified approach.
• Testing a Primary and a Secondary Endpoint in a Group Sequential Design

Cited in

(3)

• A preplanned multi-stage platform trial for discovering multiple superior treatments with control of FWER and power
• Making all pairwise comparisons in multi-arm clinical trials without control treatment
• Interim analysis in sequential multiple assignment randomized trials for survival outcomes

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