Nonparametric sequential testing in clinical trials with incomplete multivariate observations

DOI10.1093/BIOMET/78.1.123MaRDI QIDQ5748769zbMATH OpenOpenAlexFDO

Authors D. Y. Lin

Publication date 1991

Published in Biometrika (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1093/biomet/78.1.123

zbMATH Keywords

AIDSasymptotic joint distributionasymptotic powerinterim analysislocal alternativesmartingalemultiple endpointsoverall significance levelrandomized clinical trialsrepeated significance testingStopping boundariestime-to-event variablesweighted sum of the linear rank statistics

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Sequential statistical analysis (62L10) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cited in

(17)

• Multistage nonparametric tests for treatment comparisons in clinical trials with multiple primary endpoints
• On the efficiency of nonparametric variance estimation in sequential dose-finding
• Group-sequential logrank methods for trial designs using bivariate non-competing event-time outcomes
• scientific article; zbMATH DE number 70020 (Why is no real title available?)
• Directional Tests for the Analysis of Clinical Trials with Multiple Endpoints Allowing for Incomplete Data
• Analyzing multiple end points with a two-stage design in clinical trials
• An Adaptive Approach to Implementing Bivariate Group Sequential Clinical Trial Designs
• Closed Testing Procedures for Group Sequential Clinical Trials with Multiple Endpoints
• Nonparametric Rank‐Based Methods for Group Sequential Monitoring of Paired Censored Survival Data
• A Bayesian Group Sequential Approach for Multiple Endpoints
• scientific article; zbMATH DE number 774864 (Why is no real title available?)
• Advances in medical statistics arising from the AIDS epidemic
• An Introduction to Practical Sequential Inferences via Single-Arm Binary Response Studies Using the binseqtest R Package
• Confirmatory adaptive designs for clinical trials with multiple time-to-event outcomes in multi-state Markov models
• Oncology clinical trial design planning based on a multistate model that jointly models progression-free and overall survival endpoints
• Group sequential testing of a treatment effect using a surrogate marker
• Completeness and unbiased estimation of mean vector in the multivariate group sequential case

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