Optimal dynamic instability of microtubules

DOI10.4171/DMS/1-3/61MaRDI QIDQ1126860zbMATH OpenFDO

Authors Charles S. Peskin

Publication date 6 August 1998

Published in Documenta Mathematica (Search for Journal in Brave)

Full work available at URL https://eudml.org/doc/224095, http://www.emis.de/journals/DMJDMV/xvol-icm/16/Peskin.MAN.html

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zbMATH Keywords

chromosomesdynamic instabilitykinetochoremicrotubulespolymerization

Mathematics Subject Classification ID

Biophysics (92C05) Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Review text

Summary: Microtubules are polymers that play many important structural and functional roles within biological cells, including the separation of newly replicated chromosomes into the daughter cells during cell division. In order to catch the chromosomes that they must transport, microtubules grow out of the centrosome in each of the daughter cells. For any particular microtubule, epochs of steady growth are punctuated by episodes of rapid decay; this is known as dynamic instability. It allows for multiple attempts on the part of each microtubule to hit the small target at the center of each chromosome known as the kinetochore, where the microtubule can attach and apply traction to the chromosome. The optimal design of dynamic instability is the subject of this paper.

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(4)

• Exploring the effect of end-binding proteins and microtubule targeting chemotherapy drugs on microtubule dynamic instability
• Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry.
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