Optimal scheduling for cell synchronization by cycle-phase-specific blockers

DOI10.1016/0025-5564(83)90087-1MaRDI QIDQ594788zbMATH OpenOpenAlexFDO

Authors B. F. Dibrov, A. M. Zhabotinsky, Yu. A. Neyfakh, M. P. Orlova, L. I. Churikova

Publication date 1983

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(83)90087-1

zbMATH Keywords

optimal schedulingcancer chemotherapyPontryagin maximum principlebang-bang controldifference-differential equationscell synchronizationcycle-phase-specific blockersgeneral kinetic model of cell cyclestationary populations

Mathematics Subject Classification ID

Medical applications (general) (92C50) Population dynamics (general) (92D25) Control problems for functional-differential equations (34K35) Optimality conditions (49K99)

Cites work

• scientific article; zbMATH DE number 3644840 (Why is no real title available?)
• scientific article; zbMATH DE number 3286350 (Why is no real title available?)
• A method for the measurement of variability in cell lifetimes
• Mathematical models of the cell cycle with a view to tumor studies
• ON THE ROLE OF VARIABLE GENERATION TIME IN THE DEVELOPMENT OF A STOCHASTIC BIRTH PROCESS
• Tumor growth and chemotherapy: Mathematical methods, computer simulations, and experimental foundations

Cited in

(6)

• Estimation and prediction of cell cycle specific effects of anticancer drugs
• Parameter-dependent transitions and the optimal control of dynamical diseases
• Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy
• Role of optimal control theory in cancer chemotherapy
• THREE TYPES OF SIMPLE DDE'S DESCRIBING TUMOR GROWTH
• Resonance phenomena in cell population chemotherapy models

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