Optimizing Restriction Site Placement for Synthetic Genomes

DOI10.1007/978-3-642-13509-5_29MaRDI QIDQ3575258zbMATH OpenOpenAlexFDO

Authors Pablo Montes, Heraldo Memelli, Joondong Kim, Joseph S. B. Mitchell, Charles B. Ward, Steven Skiena

Publication date 26 July 2010

Published in Combinatorial Pattern Matching (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/978-3-642-13509-5_29

zbMATH Keywords

genome refactoringrestriction enyzme placementsynthetic biology

Mathematics Subject Classification ID

Computational difficulty of problems (lower bounds, completeness, difficulty of approximation, etc.) (68Q17) Problem solving in the context of artificial intelligence (heuristics, search strategies, etc.) (68T20) Computational methods for problems pertaining to biology (92-08) Biochemistry, molecular biology (92C40) Genetics and epigenetics (92D10)

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• Codon optimization by 0-1 linear programming
• RESCOT: restriction enzyme set and combination optimization tools for rNMP capture techniques
• Optimizing restriction site placement for synthetic genomes

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