Pairwise comparisons for parallel profile models with mixed effects

DOI10.2478/V10127-012-0007-YMaRDI QIDQ2913238zbMATH OpenOpenAlexFDO

Authors Hiroto Hyakutake

Publication date 26 September 2012

Published in Tatra Mountains Mathematical Publications (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.2478/v10127-012-0007-y

zbMATH Keywords

confidence intervalnonlinear modelrepeated measurements

Mathematics Subject Classification ID

General nonlinear regression (62J02) Paired and multiple comparisons; multiple testing (62J15)

Review text

A method for constructing approximate simultaneous confidence intervals for level differences in a mixed effects nonlinear parallel profile model is suggested and their statistical properties are studied and compared by Monte Carlo simulations.NEWLINENEWLINEThe considered nonlinear mixed effect model is useful for modelling and data analysis which typically arise in pharmacokinetics and/or in general class of growth processes, when the (nonlinear) group mean functions are possibly parallel, however, depend on random effects of the the individual subjects. In such situations, a pairwise comparison of level differences is of particular interest.NEWLINENEWLINEThe suggested approach is based on a novel iterative estimation procedure, which in first step uses the EGLS procedure (estimated generalized least squares) for estimation of the fixed effects parameters (of the nonlinear mean functions) in an approximate model (approximated by the first-order Taylor expansion), then estimates the variance-covariance components, and finally estimates the fixed effect parameters representing the level differences. The author considers and compares two estimators for the level differences. Based on such estimators of the approximate model, Tukey's method is used to construct simultaneous confidence intervals for pairwise comparison.

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Cites work

• Confidence regions of parameters in a nonlinear repeated measurement model with mixed effects
• scientific article; zbMATH DE number 3945094 (Why is no real title available?)
• Multiple Comparisons
• Multiple directional decision with A control in parallel profile model
• Profile analysis of several groups
• Statistical Methods for the Analysis of Repeated Measurements

Cited in

(4)

• scientific article; zbMATH DE number 445255 (Why is no real title available?)
• Confidence intervals for the difference of two functions of parameters in nonlinear repeated measurements
• Multiple comparisons in nonlinear repeated measurements
• Testing parallelism and confidence intervals of level difference in an intraclass correlation model with monotone missing data

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