Planning multi-arm screening studies within the context of a drug development program

DOI10.1002/SIM.5787MaRDI QIDQ6962480zbMATH OpenFDO

Authors James Wason, Thomas Jaki, Nigel Stallard

Publication date 8 July 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.5787

zbMATH Keywords

multi-arm multi-stage trialsoptimal designphase II trialsscreening trials

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A comparison of methods for adaptive treatment selection
• A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection
• A Simplex Method for Function Minimization
• A Two-Stage Design for Choosing among Several Experimental Treatments and a Control in Clinical Trials
• scientific article; zbMATH DE number 1348603 (Why is no real title available?)
• Two-stage selection and testing designs for comparative clinical trials

Cited in

(2)

• A comparison of Bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials
• New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation study

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