Population dynamics of gene transfer
bacterial populationscontagious genetic elementsdensity dependent competitionevolutionary dynamicsgene transferhorizontal transfer of nucleic acid sequencesintertypeintratypelimit cyclesmultiple stable interior steady statesnumerical integrationreplicationstable boundary steady statestransmission
Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Stability theory for smooth dynamical systems (37C75) Applications of dynamical systems (37N99) Probabilistic models, generic numerical methods in probability and statistics (65C20) Physiological, cellular and medical topics (92Cxx) Genetics and epigenetics (92D10) Population dynamics (general) (92D25)
This paper studies the dynamics of a genetic element which promotes its own transmission by replication within cell lineages and by horizontal transfer to element-free cells. The authors use ordinary differential equations to describe the evolutionary dynamics. The dynamical stability of two models is analysed; they differ by the presence or absence of density dependent competition between the individuals of a given type (intratype) or of both types (intertype). In the case of gene transfer without competition, even though the stability analysis allows instabilities leading to limit cycles, no such cases have been found by numerical integration. The model with competition allows a large range of dynamical behaviours: multiple stable interior steady states, limit cycles and stable interior steady states along with stable boundary steady states. The study shows that contagious genetic elements can readily spread through unicellular populations, provided they are sufficiently efficient and not overly deleterious, though they need not be beneficial. Another result is the demonstration that it is possible to completely lose element-bearing cells from the population without density-dependent competition. Finally, the study proves that effective displacement of element-free cells requires unlimited population growth.
- Stochastic analysis of emergence of evolutionary cyclic behavior in population dynamics with transfer
- POPULATION DYNAMICS OF TRANSPOSABLE ELEMENTS: COPY NUMBER REGULATION AND SPECIES INVASION REQUIREMENTS
- The effect of competition and horizontal trait inheritance on invasion, fixation, and polymorphism
- Towards a quantitative understanding of horizontal gene transfer: a kinetic model
- A branching-process model for the evolution of transposable elements incorporating selection
- The early phase of a bacterial insertion sequence infection
- Eigensolutions and spectral analysis of a model for vertical gene transfer of plasmids
- Towards a quantitative understanding of horizontal gene transfer: a kinetic model
- Selfish intracellular replicators: a two-level selection minimalist mathematical model
- The effect of competition and horizontal trait inheritance on invasion, fixation, and polymorphism
- scientific article; zbMATH DE number 1568295 (Why is no real title available?)
- Fixation probability of mobile genetic elements such as plasmids
- Transporting stochastic direct and indirect effects to new populations
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