A method of solution for a non-linear diffusion model and for computing the parameters in the model

DOI10.1016/0377-0427(87)90156-7MaRDI QIDQ1093585zbMATH OpenOpenAlexFDO

Authors Jacob Spoelstra, D. J. Van Wyk

Publication date 1987

Published in Journal of Computational and Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0377-0427(87)90156-7

zbMATH Keywords

coupled nonlinear parabolic differential equationsdonor celldrug concentrationdrug diffusionimplicit finite difference methoditerative procedureoptimization procedurereceiver cellskin-like membrane

Mathematics Subject Classification ID

Nonlinear initial, boundary and initial-boundary value problems for linear parabolic equations (35K60) Inverse problems for PDEs (35R30) Numerical optimization and variational techniques (65K10) Finite difference methods for boundary value problems involving PDEs (65N06) Medical applications (general) (92C50) Physiological, cellular and medical topics (92Cxx)

Review text

The diffusion of a drug through a skin-like membrane which tends to partially absorbing the drug, is modelled in the following way: Let a denote the thickness of the membrance, c(x,t), z(x,t) the concentration of diffusing and absorbed drug, resp., inside the membrance \((0<x<a)\), and \(c_ 1(t)\), \(c_ 2(t)\) the drug concentration in the donor cell \((x<0)\) and receiver cell \((x>a)\), resp. Then the process is described by the system of coupled nonlinear parabolic differential equations: \[ (1)\quad c_ t=(P(z,c)c_ x)_ x-z_ t,\quad z_ t=gc \] (0\(<x<a\), \(t>0)\), with boundary conditions \(c(0,t)=kc_ 1(t)\), \(c(a,t)=kc_ 2(t)\), \(\partial c_ 1/\partial t=DPc_ x(0,t),\partial c_ 2/\partial t=-DPc_ x(a,t)\) \((t>0)\) and initial conditions \(c_ 1(0)=C_ 0\), \(c_ 2(0)=0\), \(c(x,0)=0\) \((0<x<a)\). The diffusion coefficient is assumed to be given by \[ (2)\quad P(z,x)=P_ 0\exp (-b(z/(1+c))^ 2). \] The equations (1) are solved by an implicit finite difference method employing an iterative procedure at every time step. The model parameters \(P_ 0\), b, k, g, \(C_ 0\) are computed by means of an optimization procedure: the system (1), (2) is repeatedly solved for different sets of parameters, and the sum of the squares of the differences between model outputs and experimental data is minimized.

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