Pool size and mass flux bounds and quasiidentifiability relations for catenary models

DOI10.1016/0025-5564(88)90045-4MaRDI QIDQ1102219zbMATH OpenOpenAlexFDO

Authors Joseph J. III DiStefano, Elliot M. Landaw, B. C. Chen

Publication date 1988

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(88)90045-4

zbMATH Keywords

boundsmass fluxespool sizesquasiidentifiabilitysteady state residence timesunidentifiable catenary compartmental models

Mathematics Subject Classification ID

Computational methods for problems pertaining to biology (92-08) System identification (93B30)

Review text

Closed-form algorithms were recently reported by the authors [ibid. 76, 59-68 (1985; Zbl 0574.93017) and ibid. 72, 199-212 (1984; Zbl 0557.92004)] for computing the identifiable parameter combinations (structural invariants) and parameter bounds for all of the rate constants \(k_{ij}\), of unidentifiable catenary compartmental models with input and output in pool 1 only. These results are extended here, providing bounds for unidentifiable (interval identifiable) steady state residence times, pool sizes, and mass fluxes, as well as some relationships for assessing quasiidentifiability for this class of catenary models.

Recommendations

• Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models
• Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants
• Indistinguishability and identifiability analysis of linear compartmental models
• An algorithm for the identifiable parameter combinations of the general mammillary compartmental model
• Statistical variability of parameter bounds for n-pool unidentifiable mammillary and catenary compartmental models

Cites work

• Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models
• An algorithm for the identifiable parameter combinations of the general mammillary compartmental model
• Analysis of unique structural identifiability via submodels
• Complete parameter bounds and quasiidentifiability conditions for a class of unidentifiable linear systems
• Hidden pools, hidden modes, and visible repeated eigenvalues in compartmental models
• Stochastic parameters in compartmental systems

Cited in

(6)

• Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models
• Statistical variability of parameter bounds for n-pool unidentifiable mammillary and catenary compartmental models
• An algorithm for identifiable parameters and parameter bounds for a class of cascaded mammillary models
• Partial identification of underdetermined compartmental models: A method based on positive linear Lyapunov functions
• Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants
• A state space transformation can yield identifiable models for tracer kinetic studies with enrichment data

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