Statistical variability of parameter bounds for n-pool unidentifiable mammillary and catenary compartmental models

DOI10.1016/0025-5564(88)90013-2MaRDI QIDQ1109701zbMATH OpenOpenAlexFDO

Authors Robert Lindell, Elliot M. Landaw, Joseph J. III DiStefano

Publication date 1988

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(88)90013-2

zbMATH Keywords

Laplace transformcoefficient of variationMonte Carlo simulationsstructural invariantsdata-error modelsestimation of parameter boundsinterval identifiable modelsoutput data errorsoutput sensitivity functionsunidentifiable n-pool mammillary and catenary compartmental modelsvariance algorithmvariances of parameter bounds

Mathematics Subject Classification ID

Sensitivity (robustness) (93B35) Computational methods for problems pertaining to biology (92-08) General biology and biomathematics (92B05) System identification (93B30) Control/observation systems governed by ordinary differential equations (93C15)

Recommendations

• Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants
• Linear n-compartment catenary models: Formulas to describe tracer amount in any compartment and identification of parameters from a concentration- time curve
• Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models
• Pool size and mass flux bounds and quasiidentifiability relations for catenary models
• An algorithm for the identifiable parameter combinations of the general mammillary compartmental model

Cites work

• scientific article; zbMATH DE number 3673920 (Why is no real title available?)
• Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models
• An algorithm for the identifiable parameter combinations of the general mammillary compartmental model
• Analysis of unique structural identifiability via submodels
• Asymptotic Properties of Non-Linear Least Squares Estimators
• Complete parameter bounds and quasiidentifiability conditions for a class of unidentifiable linear systems
• Linear Statistical Inference and its Applications

Cited in

(8)

• A state space transformation can yield identifiable models for tracer kinetic studies with enrichment data
• An algorithm for the identifiable parameter combinations of the general mammillary compartmental model
• Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants
• Parameter identification in n-compartment mamillary models
• Algorithms for the identifiable parameter combinations and parameter bounds of unidentifiable catenary compartmental models
• Pool size and mass flux bounds and quasiidentifiability relations for catenary models
• On the computation of output bounds for compartmental in-series models under parametric uncertainty
• A Unified Approach to Variability in Compartmental Models

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