Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors

DOI10.1016/0025-5564(79)90005-1MaRDI QIDQ1134023zbMATH OpenOpenAlexFDO

Authors Suresh Moolgavkar, David J. Venzon

Publication date 1979

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(79)90005-1

zbMATH Keywords

carcinogenesisHazard functionincidence curvesone-mutation modelPoisson processprobability of malignancytwo-mutation modeltwo-stage model

Mathematics Subject Classification ID

Applications of branching processes (60J85) Applications of statistics to biology and medical sciences; meta analysis (62P10) General biology and biomathematics (92B05) Physiological, cellular and medical topics (92Cxx) Population dynamics (general) (92D25)

Cites work

• Birth-and-death processes, and the theory of carcinogenesis
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Cited in

(73)

• Studying health histories of cancer: A new model connecting cancer incidence and survival
• On the assessment of effects of environmental agents on cancer tumor development by a two-stage model of carcinogenesis
• Some mixed models of carcinogenesis
• An age-dependent stochastic model for carcinogenesis
• Scalable relative effectiveness models
• Cancer chemotherapy with immunostimulation: A nonhomogeneous stochastic model for drug resistance. I: One drug case
• An integral characterization problem in an age-dependent cancer model
• A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
• A model of multiple tumorigenesis allowing for cell death: Quantitative insight into biological effects of urethane
• Two stage model for carcinogenesis: Number and size distributions of premalignant clones in longitudinal studies
• Modeling radioprotective mechanisms in the dose effect relation at low doses and low dose rates of ionizing radiation
• Modeling insight into spontaneous regression of tumors
• Quantitative analysis of two-dimensional observations of premalignant clones in the presence or absence of malignant tumors
• A stem cell model for carcinogenesis
• Do cells repair precancerous lesions induced by radiation?
• A carcinogenesis model describing mutational events at the DNA adduct level
• Determinability of model parameters in a two-stage deterministic cancer model
• Early HIV infection in vivo: branching-process model for studying timing of immune reponses and drug therapy
• A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells
• Stochastic modeling of carcinogenesis: Some new insights
• Multitype branching processes with disasters. I: The number of particles in the system
• Testing goodness of fit for stochastic models of carcinogenesis
• The impact of radiation on the development of lung cancer
• Asymptotic relative risk results from a simplified armitage and doll model of carcinogenesis
• Epidemiologically based environmental risk assessment
• Multistage carcinogenesis and the fraction at risk
• A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data
• A stochastic model of radiation carcinogenesis: Latent time distributions and their properties
• A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data
• Calculating tumor incidence rates in stochastic models of carcinogenesis
• A stochastic model for multistage tumorigenesis in developing and adult mice
• An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth
• A diversity of responses displayed by a stochastic model of radiation carcinogenesis allowing for cell death
• Stochastic simulation of a multistage model of carcinogenesis
• A biologically based model for the analysis of premalignant foci of arbitrary shape
• Identifiability of parameters in the Yakovlev-Polig model of carcinogenesis
• Incorporating observability thresholds of tumors into the two-stage carcinogenesis model
• Combined effect of multiple carcinogens and synergy index
• A stochastic model for the sizes of detectable metastases
• Two-mutation model for carcinogenesis: Joint analysis of premalignant and malignant lesions
• Identifiability of the joint distribution of age and tumor size at detection in the presence of screening
• Comparison of multi-stage dose-response mixture models, with applications
• An application of a two-level non-Gaussian state-space model in the analysis of longitudinal papilloma count data
• A generalized Luria-Delbrück model
• Gestational mutations and carcinogenesis
• The Dynamic Model for Cancer Relapse Based on Two-Stage Model of Carcinogenesis
• Dose-response models for time-to-response toxicity data
• A nonhomogeneous two-stage model of carcinogenesis
• On semi-markov compartmental models with branching particles under the influence of disasters
• New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms
• Solution to the hazard function of some two-stage carcinogenesis models when normal cell growth is piecewise linear
• Estimating the probability of initiated cell death before tumor induction
• Models for Survival Data from Cancer Prevention Studies
• Mathematical modeling of female breast cancer in Japan
• Mathematical model of colorectal cancer initiation
• Estimation of accelerated failure time due to exposure risk using piecewise-exponential model in cohort follow-up study
• A mixed model of carcinogenesis with applications to retinoblastoma
• Statistical advances in environmental science
• Assessing effects of changing environment by a multiple pathway model of carcinogenesis
• Modeling cancer detection: Tumor size as a source of information on unobservable stages of carcinogenesis
• Using a stochastic model to analyze the sequence of phenotypic changes in rat liver focal lesions
• The shape of the hazard function for cancer incidence
• Optimal schedules of cancer surveillance and tumor size at detection
• Model oriented statistical analysis for cancer problems
• Two-stage clonal expansion model using conditional likelihood to discern the initiation and promotion effects: numerical study
• Novel predictions of invasive breast cancer risk in mammography screening cohorts
• Age-period-cohort approaches to back-calculation of cancer incidence rate
• Optimal screening schedules for prevention of metastatic cancer
• A stochastic two-stage carcinogenesis model: A new approach to computing the probability of observing tumor in animal bioassays
• Two-stage stochastic model for carcinogenesis with time-dependent parameters
• The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments
• A two-phase Poisson process model and its application to analysis of cancer mortality among A-bomb survivors
• Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach

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