A diffusion process with killing: The time to formation of recurrent deleterious mutant genes

DOI10.1016/0304-4149(82)90012-6zbMath0487.92011OpenAlexW2044581958MaRDI QIDQ1165791

Samuel Karlin, Simon Tavaré

Publication date: 1982

Published in: Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0304-4149(82)90012-6

zbMATH Keywords

finite populationdiffusion approximationsMarkov chain modelsgenotypesformation of recurrent deleterious mutant genesinfinitesimal driftkilling timesstate-dependent killing rate

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Genetics and epigenetics (92D10) Continuous-time Markov processes on discrete state spaces (60J27) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70)

Related Items (7)

Conditioning diffusion processes with killing rates ⋮ Conditioning diffusion processes with respect to the local time at the origin ⋮ Associated Stieltjes-Carlitz polynomials and a generalization of Heun's differential equation ⋮ Joint distribution of two local times for diffusion processes with the application to the construction of various conditioned processes ⋮ A diffusion approach to approximating preservation probabilities for gene duplicates ⋮ Waiting with and without recombination: The time to production of a double mutant ⋮ Some results on co-recursive associated Meixner and Charlier polynomials

Cites Work

• The detection of particular genotypes in finite populations I. Natural selection effects
• The detection of particular genotypes in finite populations II. The effects of partial penetrance and family structure
• On the past history of an allele now known to have frequencyp
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