A diffusion process with killing: The time to formation of recurrent deleterious mutant genes

DOI10.1016/0304-4149(82)90012-6zbMath0487.92011MaRDI QIDQ1165791

Simon Tavaré, Samuel Karlin

Publication date: 1982

Published in: Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0304-4149(82)90012-6

zbMATH Keywords

finite population; diffusion approximations; Markov chain models; genotypes; formation of recurrent deleterious mutant genes; infinitesimal drift; killing times; state-dependent killing rate

Mathematics Subject Classification ID

60J20: Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.)

92D10: Genetics and epigenetics

60J27: Continuous-time Markov processes on discrete state spaces

60J70: Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.)

Related Items

Waiting with and without recombination: The time to production of a double mutant, Some results on co-recursive associated Meixner and Charlier polynomials, Associated Stieltjes-Carlitz polynomials and a generalization of Heun's differential equation, A diffusion approach to approximating preservation probabilities for gene duplicates

Cites Work

• The detection of particular genotypes in finite populations I. Natural selection effects
• The detection of particular genotypes in finite populations II. The effects of partial penetrance and family structure
• On the past history of an allele now known to have frequencyp
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