A theoretical approach to G-protein modulation of cellular responsiveness

DOI10.1007/S002850050068MaRDI QIDQ1365078zbMATH OpenOpenAlexWikidataFDO

Authors Jürgen Nauroschat, Uwe an der Heiden

Publication date 28 August 1997

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s002850050068

zbMATH Keywords

\(G\)-protein\(G\)-protein coupled receptor kinasedesensitizationhormonal processingnegative feedbacktransmembrane signalling

Mathematics Subject Classification ID

Growth and boundedness of solutions to ordinary differential equations (34C11) Qualitative theory for ordinary differential equations (34C99) Stability theory for ordinary differential equations (34D99) Biochemistry, molecular biology (92C40)

Recommendations

• Modeling and optimization of G-protein coupled receptor signal transduction
• Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy
• Modelling the effect of caveolae on G-protein activation
• Modulation of the camp response by \(\mathrm{G}\alpha _i\) and \(\mathrm{G}\beta \gamma \): a computational study of G protein signaling in immune cells
• Mathematical model investigations of signal transduction via \(G\)-protein coupled receptors: trafficking and promiscuous coupling of receptors
• Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor
• Modelling the activation of G-protein coupled receptors by a single drug
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
• Enhancer and competitive allosteric modulation model for G-protein-coupled receptors

Cited in

(15)

• A \(G\) protein-based model of adaptation in Dictyostelium discoideum
• Dynamical analysis of cellular networks based on the Green's function matrix
• Exact analysis of intrinsic qualitative features of phosphorelays using mathematical models
• A simple reaction kinetic model of rapid (G protein dependent) and slow (\(\beta\)-Arrestin dependent) transmission
• Adaptive response and enlargement of dynamic range
• Metabotropic receptor activation, desensitization and sequestration. I: Modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation
• Necessary conditions for a minimal model of receptor to show adaptive response over a wide range of levels of stimulus
• A process model of Rho GTP-binding proteins
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
• Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition
• Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism
• Stability analysis of a signaling circuit with dual species of gtpase switches
• Weakly nonlinear analysis of a model of signal transduction pathway involving membrane based receptors
• Modelling and mathematical analysis of the M₂ receptor-dependent joint signalling and secondary messenger network in CHO cells
• Modulation of the camp response by \(\mathrm{G}\alpha _i\) and \(\mathrm{G}\beta \gamma \): a computational study of G protein signaling in immune cells

This page was built for publication: A theoretical approach to \(G\)-protein modulation of cellular responsiveness

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1365078)