Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition

DOI10.1016/J.MBS.2009.11.005MaRDI QIDQ2379633zbMATH OpenOpenAlexWikidataFDO

Authors L. J. Bridge, S. J. Hill, M. R. Owen, J. R. King

Publication date 19 March 2010

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2009.11.005

zbMATH Keywords

agonist-antagonist competitionasymptotic analysiscell signallingG-protein coupled receptors

Mathematics Subject Classification ID

Probabilistic models, generic numerical methods in probability and statistics (65C20) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

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Cites work

• A theoretical approach to \(G\)-protein modulation of cellular responsiveness
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
• Modelling the activation of G-protein coupled receptors by a single drug

Cited in

(15)

• Modelling the activation of G-protein coupled receptors by a single drug
• Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor
• Enhancer and competitive allosteric modulation model for G-protein-coupled receptors
• G-protein/receptor inhibitors as blockers of receptor signaling
• Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: linear models and analytical solutions
• Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy
• Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis
• A model for carrier-mediated biological signal transduction based on equilibrium ligand binding theory
• Modeling and optimization of G-protein coupled receptor signal transduction
• Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms
• Modelling and mathematical analysis of the M₂ receptor-dependent joint signalling and secondary messenger network in CHO cells
• Mathematical model investigations of signal transduction via \(G\)-protein coupled receptors: trafficking and promiscuous coupling of receptors
• Mathematical models for the EP2 and EP4 signaling pathways and their crosstalk
• Modulation of the camp response by \(\mathrm{G}\alpha _i\) and \(\mathrm{G}\beta \gamma \): a computational study of G protein signaling in immune cells
• Modelling the effect of caveolae on G-protein activation

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