Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis

DOI10.1016/J.JTBI.2021.110996MaRDI QIDQ2670169zbMATH OpenOpenAlexWikidataFDO

Authors Carla White, Vivi Rottschäfer, L. J. Bridge

Publication date 10 March 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2021.110996

zbMATH Keywords

differential equationsdimerisationmathematical pharmacologyperturbation methodsreceptor theory

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Medical applications (general) (92C50)

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Cites work

• Identifiability of linear and nonlinear dynamical systems
• Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: linear models and analytical solutions
• Ligand-induced coupling versus receptor pre-association: cellular automaton simulations of FGF-2 binding
• Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
• Modelling the activation of G-protein coupled receptors by a single drug
• System identifiability based on the power series expansion of the solution
• Topics in mathematical pharmacology

Cited in

(5)

• Ring formation in divalent-receptor-divalent-ligand interaction: Pseudocooperative shapes of Scatchard plots
• Generalized concentration addition for ligands that bind to homodimers
• Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: linear models and analytical solutions
• Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms
• A method to calculate binding equilibrium concentrations in the allosteric ternary complex model that supports ligand depletion

Describes a project that uses

Uses Software

• Matlab
• COPASI

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